Aging is known as the physiological change that happens in everyone’s life, and it is a natural process on which survival and fertility depend. Everybody holds the desire to revive their youthfulness even when they age. This is the reason both men and women do look for ways to slow down the aging process.
Over the years, researchers have made several discoveries related to the anti-aging properties of different substances. In the research, it has been found that Nicotinamide Mononucleotide (NMN) is one such substance. It helps in rejuvenating the cells and repairs the cell components of mitochondria.
Moreover, the functions of NMN aren’t limited, they are many, and to know more about them, you should read below.
What is NMN?
Nicotinamide Mononucleotide (NMN) is a naturally occurring molecule and is the derivative of vitamin B-3. It enacts the role of direct precursor in boosting NAD+ levels in human bodies.
NMN suppresses age-related weight gain, enhances energy metabolism, improves insulin sensitivity, improves eye function, and even helps in preventing age-related changes in gene expression. NMN carries the potential of suppressing the increasing inflammation linked with aging. Many types of researches have proved that NMN can lower adipose tissue inflammation linked with age.
Nicotinamide Mononucleotide is known as the part of nucleotides, organic molecules which work as the building blocks of RNA and DNA. It is made up of nitrogenous base, sugar, and the phosphate group. It is the main component that helps in creating adenine dinucleotide (NADH). NMN also gets absorbed in the gut through fatty tissues, small intestine, liver, and pancreas.
This compound can slow down cognitive decline and reduce down the risk of Alzheimer’s disease. It helps in improving the surviving neurons, improves energy metabolism, and reduces reactive oxygen species. Another added advantage is that it may assist in building the integrity of the blood-brain barrier.
How Does NMN Work?
In the research, it is found that in animal cells, NMN can be directly fed into the production of NAD+, and it provides energy to cells and is known to be critical for healthy aging. Many scientists worldwide have found that two intermediates, such as nicotinamide riboside and nicotinamide mononucleotide (NMN). However, its research is known to be more extensive than others.
Several studies have suggested that supplementation of NMN precursors can boost NAD+ levels and prolong the lifespan in mice, worms, and yeast. Many symptoms of aging get linked with how mitochondria begin to work. It can fuel NAD+, and it helps in producing more ATP cells. Since NAD+ molecules are quite large; thus the NMN Supplements do help NAD+ to penetrate the cell membrane.
Thus, the molecules of NMN get combined to form an NAD+ molecule, and its effect is quite significant in the human body. It is found that NMN can be taken up into cells directly with the help of transporters, and it helps in improving the generation of NAD by the NMN’s transporter called Slc12a8.
Significance of NMN supplement
NMN helps in boosting NAD+ levels, and this has been proven in many metabolic reactions too. According to science, the decline in the NAD+ level tends to happen when human beings age, but its effect can also be reversed.
Many studies from reputed institutes such as Harvard University and Washington University have shown that NMN molecules can be supplemented and promote longevity. Moreover, the published from Imai has indicated that an upsurge in NMN synthesis. It further proved that NMN provides neuroprotective and metabolic benefits to mice. It doubles the heart’s contractile capacity in the heart disease mouse model. In addition, it can boost cognitive measurement twice in mice after chemotherapy.
It also doubles the flexibility and elasticity of blood vessels to reverse the functional decline in mice. In addition, research and clinical trials have proved that NMN supplements can boost NAD+ to higher levels. It helps make NAD+ molecules remain more available to SIRT1 genes and increases their ability to protect the body against diseases and deterioration.
Many researchers have found that NAD+ does carry an essential role in regulating the immune systems. Earlier, NAD+ is the critical element that helped fuel the supply of cells, but in today’s time, NMN is regarded as the only pathway of contributing energy to cells.
NMN is one such molecule that helps an individual fight against metabolic diseases like dyslipidemia and non-alcoholic fatty liver disease. These types of conditions are caused due to the reduction in NAD+ levels. NMN works through the salvage pathway in boosting the NAD+ levels and even helps in declining the other diseases. Moreover, it helps in reactivating the faltering blood flow. Thus, it proves that NMN is highly significant.
Benefits of NMN
As human beings age, the NAD+ level in our body gets declined, and the need of taking NMN arises too. Thus, being a therapeutic molecule, it also carries an abundance of benefits. From protecting your heart to promoting energy metabolism, this supplement brings an ample amount of health benefits.
Protects Cardiovascular Function
The supplementation of NMN helps in protecting the cardiovascular system of human beings through different mechanisms. It holds the ability to encourage glycolysis that aids in the creation of ATP cells. NMN helps in alleviating heart muscle enlargement as well as tissue disorganization in chemically-induced scar tissue build-up.
It activates cell-health maintaining proteins to inhibit genes that facilitate fibrosis and dysfunction. Thus, it works as an essential precursor in supplying bioenergetic molecules in all types of cells. It even helps in mitigating scar tissue formed in the kidney and liver. NMN preserves mitochondrial ultra-structure, reduced ROS, and prevents the occurring of cell death in the heart. It also helps in stabilizing cardiac cells to make a steady supply of NMN.
Another added advantage of NMN is that its molecules can quickly turn into NAD+ within the heart system. Therefore, it gets considered to be a necessary molecule for supporting the circulatory system.
Lowers Risk of Obesity
NMN helps in reducing down the risks linked with obesity as well as other metabolic diseases. This is backed by the research conducted on mice studies which proved that NMN carries an effect of calorie restriction. Moreover, calorie restriction is shown to provide numerous benefits linked with aging and health.
It helps produce sirtuins that controlled stored fat and can be used by cells directly and indirectly. It allows sirtuins to prevent the generation of fat cells in adipose tissues. It even turns fat into energy and protects skeletal muscles and the liver from becoming the center of deposition of muscles and liver.
Enhances Maintenance of DNA Repair
The compound NMN can activate the group of proteins called sirtuins, which further help in boosting NAD+ levels. Thus, it plays a significant role in maintaining DNA integrity. In addition, sirtuins further help in slowing down the process of cell division. Therefore, to function properly, sirtuins depend upon NAD+.
It is found that NMN help in boosting NAD+ levels and further assists the DNA repair protein called PARP1 to enable the body to function smoothly. It helps in DNA repair and even protects against radiation-induced DNA damage. With the mechanism of boosting NAD+, it promotes PARPA1, which helps to reduce the ability of DBC1.
Boosts Mitochondrial Function
The supplementation of NMN further helps in converting food molecules into cellular energy. It further helps in removing the mitochondrial anomalies that get cause because of the loss of NAD+. In simple words, it reduces the chances for a person to suffer from neurological disorders like Alzheimer’s.
It breaks down nutrients into energy molecules and is labeled as powerful important cell functions, and reduces oxidative stress. Thus, the biochemical processes happening through it helps in slowing down and halt the aging process. Apart from boosting energy it also repairs cells in the body.
The longevity-promoting effects related to NMN lie within its ability to promote energy metabolism. NMN is one such element that replenishes human bodies with NAD+ levels. Thus, it further helps in promoting a better quality of life and reverses the effect of anti-aging.
It is a strong, reliable NAD+ activator It works as an anti-aging molecule and is capable of increasing intracellular levels linked with NAD+ that further enhances survival rate, and also includes boosting of energy production that helps in up-regulating cellular repair
Improves Muscle Strength
Many scientific research studies have proven that NMN carries better energy metabolism with no side effects. In addition, it helps maintain the health of human muscles, and it also increases the supply of NAD+.
It helps in decreasing fat mass and eventually boosts an increase in lean mass muscle. Its supplementation will help one to lose weight and build muscle which is regarded as the two most potent paths of improving muscle health and even allow one to look younger.
Sources of NMN
NMN can be found in different foods like broccoli, cabbage, cucumber, edamame, avocadoes, nuts, and much more. It can be found in abundance in tomatoes as well as in raw beef. Thus, these foods will help you to gain health benefits.
You may also think of preparing different types of lean proteins and even consuming non-vegetarian foods rich in proteins like red meat. Do make some space for fish, seafood, and poultry in your diet because they are rich sources of lean proteins. In case if you are a vegetarian, then do prefer vegetarian options such as tofu, tempeh, nuts, eggs, beans, and legumes.
You may also think of consuming low-fat dairy items such as low-fat Greek yogurt, milk, cottage, or even cheese. You may even consume dairy-free alternatives that include soy milk and soy yogurt because they are low in fat.
Even eating whole-grain bread and cereal such as oats, brown rice, quinoa, millet, and bulgur consist of NMN in abundance. You can also think of consuming salmon, tuna, sardines, and trout because they consist of omega-3 fatty acids. As a result, these foods help decrease the risk of age-related cognitive decline and lower the development of dementia and Alzheimer’s.
The doses in human supplements may vary around a few hundred mg per day. For example, the dosage required by human beings is 125 mg NMN twice in over 8 weeks. The accurate dosage of NMN is reported to be around 250-500mg daily.
One can take NMN orally through the pill/ powder or even by keeping the capsule under the tongue. According to clinical studies, a human being can consume at least 250 mg of NMN per day. Thus, one can consume 250 mg of NMN doses per day because they are more safe and efficient.
Is NMN Safe?
NMN can boost NAD+ levels and promote healthspan in yeast, worms, and mice. Thus, it carries therapeutic properties. Many scientists worldwide have started clinical trials to understand whether NMN is safe or not and what kind of changes it brings to our bodies.
NMN does not carry any safety concerns on the consumption of single oral doses of 100, 250, and 500 mg of NMN. It doesn’t affect heart rate, blood pressure, blood oxygen levels, or even body temperature. Their research also measured sleep quality and found no difference before and after the use of NMN.
It is strongly believed that consumption of vitamins and minerals does help one to balance their diet effectively. But, if one thinks of taking the help of an NMN supplement, it can bring significant health changes.